The Alfa Romeo Brera was introduced in production form at the Geneva Motor Show in 2005.  It translated the original exterior appearance on a much smaller scale, becoming a mid-size coupé on the GM/Fiat Premium platform. A convertible Spider version of the Brera was also announced, to be launched shortly after the coupe and to replace the existing GTV-based Spider. The Brera was initially available with two petrol engines, the 185 PS (136 kW; 182 hp) 2.2-litre JTS and 260 PS (190 kW; 260 hp) 3.2-litre V6; and a 210 PS (150 kW; 210 hp) 2.4-litre JTD turbodiesel.

The New Spider version was introduced at the Geneva Motor Show in 2006. The Spider is based on the Brera coupe but is a pure 2-seater convertible. At the beginning there were two engine options available: the 2.2 L straight-4 and 3.2 L V6 JTS engines. Alfa Romeo has created a special edition of its Spider convertible in order to commemorate the historic Mille Miglia 1,000 mile race that takes place in Italy annually.